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If your search returned "Guangzhou South Railway Station," you are arriving by rail, not by air. The two Guangzhou gateways serve different directions: Baiyun International Airport (CAN) handles most international flights and some domestic routes. Guangzhou South Railway Station (GZS) is the high-speed rail hub for the city, handling the Beijing–Guangzhou corridor, the Shenzhen–Hong Kong Express Rail Link, and routes to Guangxi, Guizhou, and the Pearl River Delta cities.
The two are in different parts of the city. Baiyun Airport is north of the old city center. Guangzhou South is in Panyu District, south of the center. If you flew into CAN and are now looking at GZS, these are not interchangeable names for the same place.
For the airport side of the choice — which route arrives at which gateway and which direction Guangzhou sits in for the trip — the China airports page covers the broader gateway question. This page covers what happens after the train pulls into Guangzhou South.

Guangzhou South Station sits in Panyu District, south of the old city. The three things most visitors come to Guangzhou for are in three different directions from the station, and none of them are a short walk:


The practical implication: when the train pulls into Guangzhou South, the first decision is not which site to visit — it is which direction to head and whether to go there today or tomorrow. The city center is 15–20 km from the station. Pazhou is a different direction again. Gulongxia is a third direction entirely.
For the full Guangzhou shape, the Guangzhou itinerary page covers what fits in two or three nights. For the private ground option, the Guangzhou private tour page covers how a private vehicle changes the day.

Hotels near Guangzhou South Station are convenient for catching a connecting train the next morning. They are not convenient for a three-day city visit. Shamian Island, the Chen Clan Academy, and the old city food streets are on the western side of Guangzhou — 20–25 km from the Panyu station area. Adding that drive to every evening after a full sightseeing day is how a three-night Guangzhou trip starts to feel short.
The standard three-night Guangzhou itinerary runs:
If the trip coincides with the Canton Fair, Pazhou takes priority and the day shape changes. The fair grounds are in Haizhu District, and hotel availability in the nearby area tightens significantly during the exhibition period. The Guangzhou itinerary page covers the fair-week adjustments in more detail.
Send the arrival time, the number of nights, and whether the fair is a factor — we will tell you which direction makes sense for the arrival day and whether a hotel near the station or in the old city fits the itinerary better.